Characteristics of Depressive-Like Behavior of Prenatally Stressed Male Rats with Androgen Deficiency
- Authors: Fedotova Y.O.1, Akulova V.K.1, Pivina S.G.1
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Affiliations:
- Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Issue: Vol 162, No 5 (2017)
- Pages: 594-596
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238397
- DOI: https://doi.org/10.1007/s10517-017-3665-6
- ID: 238397
Cite item
Abstract
Characteristics of depressive-like behavior of male rats with androgen deficiency born by mothers subjected to prenatal stress during pregnancy were assessed by using Porsolt tests and open-field tests. The level of depression-like behavior in prenatally stressed males increased more intensively than in non-stressed gonadectomized males. Chronic administration of testosterone propionate (0.5 mg/kg, intramuscularly, for 14 days) increased depressive behavior in prenatally stressed gonadectomized males in contrast to its antidepressant effect in nonstressed gonadectomized rats. Prenatal stress considerably exacerbated depressive behavior of male rats under conditions of androgen deficiency and abolished the antidepressant effect of exogenously administered testosterone propionate.
About the authors
Yu. O. Fedotova
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Author for correspondence.
Email: julia.fedotova@mail.ru
Russian Federation, St. Petersburg
V. K. Akulova
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: julia.fedotova@mail.ru
Russian Federation, St. Petersburg
S. G. Pivina
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: julia.fedotova@mail.ru
Russian Federation, St. Petersburg