Nitrogen Oxide, Endothelin-1, and Serotonin in the Blood of Immature Spontaneously Hypertensive Rats
- Авторы: Chibireva M.1, Aflyatumova G.2, Matveeva V.1, Bilalova D.1, Kuz’mina O.1, Sadykova D.2, Nigmatullina R.1
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Учреждения:
- Kazan State Medical University, Ministry of Health of the Russian Federation
- Kazan State Medical Academy, Ministry of Health of the Russian Federation
- Выпуск: Том 162, № 3 (2017)
- Страницы: 310-312
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238153
- DOI: https://doi.org/10.1007/s10517-017-3602-8
- ID: 238153
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Аннотация
Endothelial function is an early and sensitive marker of subclinical increase of BP in children and adolescents. It is associated with an imbalance of the key vasoactive factors (NO, endothelin-1, and serotonin). Immature spontaneously hypertensive rats (SHR line) are characterized by increased plasma concentrations of NO and endothelin-1 (by 14.7% and 2.9 times, respectively) and increased serotonin content in the plasma and platelets (by 2.7 and 2.3 times, respectively) in comparison with Wistar-Kyoto rats. Platelet count in the blood of SHR rats is by 50% higher than in Wistar-Kyoto rats.
Об авторах
M. Chibireva
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Россия, Kazan
G. Aflyatumova
Kazan State Medical Academy, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Россия, Kazan, Tatarstan Republic
V. Matveeva
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Россия, Kazan
D. Bilalova
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Россия, Kazan
O. Kuz’mina
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Россия, Kazan
D. Sadykova
Kazan State Medical Academy, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Россия, Kazan, Tatarstan Republic
R. Nigmatullina
Kazan State Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: razinar@mail.ru
Россия, Kazan