Email this article Nitrogen Oxide, Endothelin-1, and Serotonin in the Blood of Immature Spontaneously Hypertensive Rats
- Authors: Chibireva M.D.1, Aflyatumova G.N.2, Matveeva V.L.1, Bilalova D.F.1, Kuz’mina O.I.1, Sadykova D.I.2, Nigmatullina R.R.1
-
Affiliations:
- Kazan State Medical University, Ministry of Health of the Russian Federation
- Kazan State Medical Academy, Ministry of Health of the Russian Federation
- Issue: Vol 162, No 3 (2017)
- Pages: 310-312
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238153
- DOI: https://doi.org/10.1007/s10517-017-3602-8
- ID: 238153
Cite item
Open Access
Access granted
Subscription Access
Abstract
Endothelial function is an early and sensitive marker of subclinical increase of BP in children and adolescents. It is associated with an imbalance of the key vasoactive factors (NO, endothelin-1, and serotonin). Immature spontaneously hypertensive rats (SHR line) are characterized by increased plasma concentrations of NO and endothelin-1 (by 14.7% and 2.9 times, respectively) and increased serotonin content in the plasma and platelets (by 2.7 and 2.3 times, respectively) in comparison with Wistar-Kyoto rats. Platelet count in the blood of SHR rats is by 50% higher than in Wistar-Kyoto rats.
About the authors
M. D. Chibireva
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Russian Federation, Kazan
G. N. Aflyatumova
Kazan State Medical Academy, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Russian Federation, Kazan, Tatarstan Republic
V. L. Matveeva
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Russian Federation, Kazan
D. F. Bilalova
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Russian Federation, Kazan
O. I. Kuz’mina
Kazan State Medical University, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Russian Federation, Kazan
D. I. Sadykova
Kazan State Medical Academy, Ministry of Health of the Russian Federation
Email: razinar@mail.ru
Russian Federation, Kazan, Tatarstan Republic
R. R. Nigmatullina
Kazan State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: razinar@mail.ru
Russian Federation, Kazan
Supplementary files
