Stress of the Endoplasmic Reticulum of Neurons in Stroke Can Be Maximally Limited by Combined Exposure to Hypercapnia and Hypoxia
- Авторы: Tregub P.1,2, Kulikov V.1,2, Motin Y.1, Nagibaeva M.1, Zabrodina A.1
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Учреждения:
- Altai State Medical University, Ministry of Health Care of the Russian Federation
- Research Institute of Physiology and Fundamental Medicine
- Выпуск: Том 161, № 4 (2016)
- Страницы: 472-475
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237522
- DOI: https://doi.org/10.1007/s10517-016-3441-z
- ID: 237522
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Аннотация
We studied the expression of chaperone GRP-78 and transcription factor NF-kB during the development of ischemic tolerance of the brain after combined and isolated exposure to hypoxia and hypercapnia. Combined exposure to hypoxia and hypercapnia maximally increased the expression of chaperone GRP-78 and transcription factor NF-kB, while the formation of ischemia-induced tolerance under conditions of hypercapnic hypoxia can be associated with activation of adaptive stress mechanisms in the endoplasmic reticulum. Under these conditions, hypercapnia in combination with hypoxia is a priority factor for activation of GRP-78 and transcription factor NF-kB.
Об авторах
P. Tregub
Altai State Medical University, Ministry of Health Care of the Russian Federation; Research Institute of Physiology and Fundamental Medicine
Автор, ответственный за переписку.
Email: pfiza_asmu@mail.ru
Россия, Barnaul; Novosibirsk
V. Kulikov
Altai State Medical University, Ministry of Health Care of the Russian Federation; Research Institute of Physiology and Fundamental Medicine
Email: pfiza_asmu@mail.ru
Россия, Barnaul; Novosibirsk
Yu. Motin
Altai State Medical University, Ministry of Health Care of the Russian Federation
Email: pfiza_asmu@mail.ru
Россия, Barnaul
M. Nagibaeva
Altai State Medical University, Ministry of Health Care of the Russian Federation
Email: pfiza_asmu@mail.ru
Россия, Barnaul
A. Zabrodina
Altai State Medical University, Ministry of Health Care of the Russian Federation
Email: pfiza_asmu@mail.ru
Россия, Barnaul
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