Stress of the Endoplasmic Reticulum of Neurons in Stroke Can Be Maximally Limited by Combined Exposure to Hypercapnia and Hypoxia
- Authors: Tregub P.P.1,2, Kulikov V.P.1,2, Motin Y.G.1, Nagibaeva M.E.1, Zabrodina A.S.1
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Affiliations:
- Altai State Medical University, Ministry of Health Care of the Russian Federation
- Research Institute of Physiology and Fundamental Medicine
- Issue: Vol 161, No 4 (2016)
- Pages: 472-475
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237522
- DOI: https://doi.org/10.1007/s10517-016-3441-z
- ID: 237522
Cite item
Abstract
We studied the expression of chaperone GRP-78 and transcription factor NF-kB during the development of ischemic tolerance of the brain after combined and isolated exposure to hypoxia and hypercapnia. Combined exposure to hypoxia and hypercapnia maximally increased the expression of chaperone GRP-78 and transcription factor NF-kB, while the formation of ischemia-induced tolerance under conditions of hypercapnic hypoxia can be associated with activation of adaptive stress mechanisms in the endoplasmic reticulum. Under these conditions, hypercapnia in combination with hypoxia is a priority factor for activation of GRP-78 and transcription factor NF-kB.
About the authors
P. P. Tregub
Altai State Medical University, Ministry of Health Care of the Russian Federation; Research Institute of Physiology and Fundamental Medicine
Author for correspondence.
Email: pfiza_asmu@mail.ru
Russian Federation, Barnaul; Novosibirsk
V. P. Kulikov
Altai State Medical University, Ministry of Health Care of the Russian Federation; Research Institute of Physiology and Fundamental Medicine
Email: pfiza_asmu@mail.ru
Russian Federation, Barnaul; Novosibirsk
Yu. G. Motin
Altai State Medical University, Ministry of Health Care of the Russian Federation
Email: pfiza_asmu@mail.ru
Russian Federation, Barnaul
M. E. Nagibaeva
Altai State Medical University, Ministry of Health Care of the Russian Federation
Email: pfiza_asmu@mail.ru
Russian Federation, Barnaul
A. S. Zabrodina
Altai State Medical University, Ministry of Health Care of the Russian Federation
Email: pfiza_asmu@mail.ru
Russian Federation, Barnaul