Lentiviral Transduction of Neurons in Adult Brain: Evaluation of Inflammatory Response and Cognitive Effects in Mice
- Авторы: Kunitsyna T.1, Ivashkina O.1, Roshchina M.1, Toropova K.1, Anokhin K.1
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Учреждения:
- National Research Center Kurchatov Institute
- Выпуск: Том 161, № 2 (2016)
- Страницы: 316-319
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237382
- DOI: https://doi.org/10.1007/s10517-016-3404-4
- ID: 237382
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Аннотация
We evaluated the effect of hippocampal injection of lentiviral particles p156-CMV-EGFP on behavior, learning, and microglial Iba1+ cells activation in mice. Testing in the open field and elevated plus-maze revealed higher anxiety levels in lentiviral-injected mice in comparison with animals injected with vehicle. At the same time, lentivirus injection did not change learning and memory of mice in the hippocampal-dependent fear conditioning task. Microglia density in lentivirus-injected mice was significantly higher than in vehicle-injected mice. Thus, hippocampal injection of lentiviral particles with minimum content of transgenes produced evident inflammation process, changed anxiety level of experimental animals, but had no effect on hippocampal-dependent learning and memory.
Об авторах
T. Kunitsyna
National Research Center Kurchatov Institute
Email: oivashkina@gmail.com
Россия, Moscow
O. Ivashkina
National Research Center Kurchatov Institute
Автор, ответственный за переписку.
Email: oivashkina@gmail.com
Россия, Moscow
M. Roshchina
National Research Center Kurchatov Institute
Email: oivashkina@gmail.com
Россия, Moscow
K. Toropova
National Research Center Kurchatov Institute
Email: oivashkina@gmail.com
Россия, Moscow
K. Anokhin
National Research Center Kurchatov Institute
Email: oivashkina@gmail.com
Россия, Moscow