Modification of Biochemical Properties of Nitrosothiol by Fe3+ Cation: A Presumable Physiological Role
- Autores: Titov V.1,2, Osipov A.1, Ibragimova L.1, Petrov V.1, Dolgorukova A.2
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Afiliações:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Federal Research Center — All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences
- Edição: Volume 168, Nº 1 (2019)
- Páginas: 41-44
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242182
- DOI: https://doi.org/10.1007/s10517-019-04641-7
- ID: 242182
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Resumo
In the presence of Fe3+ cation, S-nitrosoglutathione (GSNO) loses the potency to inhibit catalase in the system containing hemoglobin (an NO trap) with iron chelator or -SH inhibitor (a “sulfhydric poison” Hg2+). In the absence of hemoglobin, the inhibitory potency is retained in both cases. These properties are characteristic of dinitrosyl-iron complexes containing ferrous iron and thiols (DNIC/RSH). Since the potency to inhibit catalase results from the presence of -NO group, its loss in the presence of hemoglobin relates probably to transfer of this group to hemoglobin. The nitrosothiols are relatively stable compounds, so their ability to release NO under the action of iron chelators, which is characteristic of DNIC/RSH, can have important physiological implications, because the role of such chelators can be played by some endogenous agents as well. Thus, release of NO from the donor compounds can be controlled and regulated. Probably, the agents such as nitrosothiol+Fe3+ are the major constituents in the pool of nitroso compounds.
Sobre autores
V. Titov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation; Federal Research Center — All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences
Autor responsável pela correspondência
Email: vtitov43@yandex.ru
Rússia, Moscow; Sergiev Posad, Moscow Region
A. Osipov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vtitov43@yandex.ru
Rússia, Moscow
L. Ibragimova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vtitov43@yandex.ru
Rússia, Moscow
V. Petrov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vtitov43@yandex.ru
Rússia, Moscow
A. Dolgorukova
Federal Research Center — All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences
Email: vtitov43@yandex.ru
Rússia, Sergiev Posad, Moscow Region
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