Modification of Biochemical Properties of Nitrosothiol by Fe3+ Cation: A Presumable Physiological Role
- Авторы: Titov V.1,2, Osipov A.1, Ibragimova L.1, Petrov V.1, Dolgorukova A.2
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Учреждения:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Federal Research Center — All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences
- Выпуск: Том 168, № 1 (2019)
- Страницы: 41-44
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242182
- DOI: https://doi.org/10.1007/s10517-019-04641-7
- ID: 242182
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Аннотация
In the presence of Fe3+ cation, S-nitrosoglutathione (GSNO) loses the potency to inhibit catalase in the system containing hemoglobin (an NO trap) with iron chelator or -SH inhibitor (a “sulfhydric poison” Hg2+). In the absence of hemoglobin, the inhibitory potency is retained in both cases. These properties are characteristic of dinitrosyl-iron complexes containing ferrous iron and thiols (DNIC/RSH). Since the potency to inhibit catalase results from the presence of -NO group, its loss in the presence of hemoglobin relates probably to transfer of this group to hemoglobin. The nitrosothiols are relatively stable compounds, so their ability to release NO under the action of iron chelators, which is characteristic of DNIC/RSH, can have important physiological implications, because the role of such chelators can be played by some endogenous agents as well. Thus, release of NO from the donor compounds can be controlled and regulated. Probably, the agents such as nitrosothiol+Fe3+ are the major constituents in the pool of nitroso compounds.
Об авторах
V. Titov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation; Federal Research Center — All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: vtitov43@yandex.ru
Россия, Moscow; Sergiev Posad, Moscow Region
A. Osipov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vtitov43@yandex.ru
Россия, Moscow
L. Ibragimova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vtitov43@yandex.ru
Россия, Moscow
V. Petrov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vtitov43@yandex.ru
Россия, Moscow
A. Dolgorukova
Federal Research Center — All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences
Email: vtitov43@yandex.ru
Россия, Sergiev Posad, Moscow Region
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