Role of α-Fetoprotein in Regulation of Proliferation and Functional Activity of Naïve T Cells and Immune Memory T Cells
- Autores: Zamorina S.1, Litvinova L.2, Yurova K.2, Khaziakhmatova O.2, Timganova V.1, Bochkova M.1, Khramtsov P.1,2, Raev M.1, Chereshnev V.1,3
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Afiliações:
- Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
- I. Kant Baltic Federal University
- Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
- Edição: Volume 167, Nº 4 (2019)
- Páginas: 470-474
- Seção: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241806
- DOI: https://doi.org/10.1007/s10517-019-04552-7
- ID: 241806
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Resumo
We studied the role of native α-fetoprotein preparation in the regulation of proliferation and functional activity of naïve T cells and immune memory T cells in vitro. The study was carried out on separated fractions of naïve T cells (CD45RA+) and immune memory T cells (CD45R0+) incubated with α-fetoprotein under conditions of TCR activation. At the level of naïve T cells, α-fetoprotein in a concentration of 100 U/ml reduced the expression of CD28, but increased the expression of CD25, while at the level of immune memory T cells α-fetoprotein (50 and 100 U/ml) only suppressed the expression of CD25. No effects of α-fetoprotein on the proliferative status of the studied lymphocyte subpopulations and on the expression of CD71 (proliferation marker) by these cells were detected. Addition of α-fetoprotein in a concentration of 100 U/ml increased the level of IL-2 in naïve T cell culture supernatants, while production of IL-2 by memory T cells remained unchanged. These data demonstrated the priority aspects of regulation of the functional activities of naïve T cells and immune memory T cells.
Sobre autores
S. Zamorina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: mantissa7@mail.ru
Rússia, Perm
L. Litvinova
I. Kant Baltic Federal University
Email: mantissa7@mail.ru
Rússia, Kaliningrad
K. Yurova
I. Kant Baltic Federal University
Email: mantissa7@mail.ru
Rússia, Kaliningrad
O. Khaziakhmatova
I. Kant Baltic Federal University
Email: mantissa7@mail.ru
Rússia, Kaliningrad
V. Timganova
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: mantissa7@mail.ru
Rússia, Perm
M. Bochkova
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: mantissa7@mail.ru
Rússia, Perm
P. Khramtsov
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; I. Kant Baltic Federal University
Email: mantissa7@mail.ru
Rússia, Perm; Kaliningrad
M. Raev
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: mantissa7@mail.ru
Rússia, Perm
V. Chereshnev
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences; Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences
Email: mantissa7@mail.ru
Rússia, Perm; Yekaterinburg