Effects of Quercetin on Expression of Genes of Carbohydrate and Lipid Metabolism Enzymes in the Liver of Rats Receiving High-Fructose Ration
- Autores: Mzhel’skaya K.1, Trusov N.1, Guseva G.1, Aksenov I.1, Kravchenko L.1, Tutelyan V.1
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Afiliações:
- Federal Research Center of Nutrition and Biotechnology
- Edição: Volume 167, Nº 2 (2019)
- Páginas: 263-266
- Seção: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/241634
- DOI: https://doi.org/10.1007/s10517-019-04505-0
- ID: 241634
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Resumo
We studied the expression of genes encoding enzymes of carbohydrate and lipid metabolism ketohexokinase (Khk), glucokinase (Gck), pyruvate kinase (Pklr), acetyl-Co-carboxylase (Acaca), fatty acid synthase (Fasn), stearoyl-CoA desaturase (Scd), and their transcription regulators ChREBP (Mlxipl), SREBP-1c (Srebf1), and PPARα (Ppara) in rat liver. Control group rats received a semisynthetic ration over 20 weeks. Experimental group 1 received a semisynthetic ration and 20% fructose solution instead of drinking water. Experimental group 2 rats received a semisynthetic ration with quercetin (0.1% fodder weight) and 20% fructose solution. Consumption of 20% fructose solution (experimental group 1) led to an increase in Scd expression in comparison with the control and did not affect the expression of other genes. Addition of quercetin to the ration (experimental group 2) led to a decrease in the expression of Khk, Gck, Fasn, Scd, Mlxipl, and Ppara genes in comparison with experimental group 1. The results suggest that quercetin reduced the expression of genes of carbohydrate and lipid metabolism enzymes in the liver of rats receiving high-fructose ration.
Sobre autores
K. Mzhel’skaya
Federal Research Center of Nutrition and Biotechnology
Autor responsável pela correspondência
Email: kristik13@yandex.ru
Rússia, Moscow
N. Trusov
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
Rússia, Moscow
G. Guseva
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
Rússia, Moscow
I. Aksenov
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
Rússia, Moscow
L. Kravchenko
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
Rússia, Moscow
V. Tutelyan
Federal Research Center of Nutrition and Biotechnology
Email: kristik13@yandex.ru
Rússia, Moscow
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