State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment
- Autores: Mukhina A.1, Medvedeva O.1, Svishcheva M.1, Shevchenko A.1, Efremova N.1, Bobyntsev I.1, Kalutskii P.1, Andreeva L.2, Myasoedov N.2
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Afiliações:
- Kursk State Medical University, Ministry of Health of the Russian Federation
- Institute of Molecular Genetics, Russian Academy of Sciences
- Edição: Volume 167, Nº 2 (2019)
- Páginas: 226-228
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241600
- DOI: https://doi.org/10.1007/s10517-019-04496-y
- ID: 241600
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Resumo
We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.
Sobre autores
A. Mukhina
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Rússia, Kursk
O. Medvedeva
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Rússia, Kursk
M. Svishcheva
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Rússia, Kursk
A. Shevchenko
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Rússia, Kursk
N. Efremova
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Rússia, Kursk
I. Bobyntsev
Kursk State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: bobig@mail.ru
Rússia, Kursk
P. Kalutskii
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: bobig@mail.ru
Rússia, Kursk
L. Andreeva
Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
Rússia, Moscow
N. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
Rússia, Moscow
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