Cell Sheets of Mesenchymal Stromal Cells Effectively Stimulate Healing of Deep Soft Tissue Defects
- Autores: Aleksandrushkina N.1,2, Danilova N.3, Grigorieva O.1, Mal’kov P.3, Popov V.2, Efimenko A.1,2, Makarevich P.1,2
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Afiliações:
- Institute for Regenerative Medicine
- Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
- Department of Clinical Pathology, Medical Scientific and Educational Center, M. V. Lomonosov Moscow State University
- Edição: Volume 167, Nº 1 (2019)
- Páginas: 159-163
- Seção: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241539
- DOI: https://doi.org/10.1007/s10517-019-04482-4
- ID: 241539
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Resumo
We used rat model of splinted defect of the skin and soft tissues to compare the efficiency f mesenchymal stromal cells applied in sheets or in suspension for the treatment of these injuries. Transplantation of mesenchymal stromal cells significantly accelerated wound healing in comparison with the control. In the group treated by application of mesenchymal stromal cell sheets, the defect was closed by day 28, in the group treated with cell suspension by day 35, and in the control group after 49 days. According to histological analysis of the tissue samples, the formation of the granulation tissue and fibrosis occurred earlier after application of mesenchymal stromal cells. Application of mesenchymal stromal cells in the form of cell sheets demonstrated high efficiency, which allowed us to consider this approach as a promising method of healing of skin and soft tissue injuries.
Sobre autores
N. Aleksandrushkina
Institute for Regenerative Medicine; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Autor responsável pela correspondência
Email: n.alexandrushkina@gmail.com
Estados Unidos da América, Pittsburgh, PA; Moskva
N. Danilova
Department of Clinical Pathology, Medical Scientific and Educational Center, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
Rússia, Moscow
O. Grigorieva
Institute for Regenerative Medicine
Email: n.alexandrushkina@gmail.com
Estados Unidos da América, Pittsburgh, PA
P. Mal’kov
Department of Clinical Pathology, Medical Scientific and Educational Center, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
Rússia, Moscow
V. Popov
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
Rússia, Moskva
A. Efimenko
Institute for Regenerative Medicine; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
Estados Unidos da América, Pittsburgh, PA; Moskva
P. Makarevich
Institute for Regenerative Medicine; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
Estados Unidos da América, Pittsburgh, PA; Moskva