Cell Sheets of Mesenchymal Stromal Cells Effectively Stimulate Healing of Deep Soft Tissue Defects
- 作者: Aleksandrushkina N.1,2, Danilova N.3, Grigorieva O.1, Mal’kov P.3, Popov V.2, Efimenko A.1,2, Makarevich P.1,2
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隶属关系:
- Institute for Regenerative Medicine
- Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
- Department of Clinical Pathology, Medical Scientific and Educational Center, M. V. Lomonosov Moscow State University
- 期: 卷 167, 编号 1 (2019)
- 页面: 159-163
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241539
- DOI: https://doi.org/10.1007/s10517-019-04482-4
- ID: 241539
如何引用文章
详细
We used rat model of splinted defect of the skin and soft tissues to compare the efficiency f mesenchymal stromal cells applied in sheets or in suspension for the treatment of these injuries. Transplantation of mesenchymal stromal cells significantly accelerated wound healing in comparison with the control. In the group treated by application of mesenchymal stromal cell sheets, the defect was closed by day 28, in the group treated with cell suspension by day 35, and in the control group after 49 days. According to histological analysis of the tissue samples, the formation of the granulation tissue and fibrosis occurred earlier after application of mesenchymal stromal cells. Application of mesenchymal stromal cells in the form of cell sheets demonstrated high efficiency, which allowed us to consider this approach as a promising method of healing of skin and soft tissue injuries.
作者简介
N. Aleksandrushkina
Institute for Regenerative Medicine; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: n.alexandrushkina@gmail.com
美国, Pittsburgh, PA; Moskva
N. Danilova
Department of Clinical Pathology, Medical Scientific and Educational Center, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
俄罗斯联邦, Moscow
O. Grigorieva
Institute for Regenerative Medicine
Email: n.alexandrushkina@gmail.com
美国, Pittsburgh, PA
P. Mal’kov
Department of Clinical Pathology, Medical Scientific and Educational Center, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
俄罗斯联邦, Moscow
V. Popov
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
俄罗斯联邦, Moskva
A. Efimenko
Institute for Regenerative Medicine; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
美国, Pittsburgh, PA; Moskva
P. Makarevich
Institute for Regenerative Medicine; Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: n.alexandrushkina@gmail.com
美国, Pittsburgh, PA; Moskva