Morphological Evaluation of the Tissue Reaction to Subcutaneous Implantation of Decellularized Matrices
- Autores: Sotnichenko A.1, Nakokhov R.1, Gubareva E.1, Kuevda E.1, Gumenyuk I.1
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Afiliações:
- Kuban State Medical University
- Edição: Volume 166, Nº 2 (2018)
- Páginas: 287-292
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240974
- DOI: https://doi.org/10.1007/s10517-018-4334-0
- ID: 240974
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Resumo
Based on the data of morphological analysis, we performed histological evaluation of rat tissue reaction to subcutaneous implantation of decellularized matrices of intrathoracic organs and tissues. Cell composition of the inflammatory infiltrate was analyzed, and the dynamics of macrophage and T and B lymphocyte content was assessed on days 7 and 14 of the experiment. It was found that the reaction to implantation depended not only on the quality of decellularization and efficiency of removal of antigen molecules, but also on the original histological structure and quality of preimplantation processing of the transplant.
Sobre autores
A. Sotnichenko
Kuban State Medical University
Autor responsável pela correspondência
Email: alex24.88@mail.ru
Rússia, Krasnodar
R. Nakokhov
Kuban State Medical University
Email: alex24.88@mail.ru
Rússia, Krasnodar
E. Gubareva
Kuban State Medical University
Email: alex24.88@mail.ru
Rússia, Krasnodar
E. Kuevda
Kuban State Medical University
Email: alex24.88@mail.ru
Rússia, Krasnodar
I. Gumenyuk
Kuban State Medical University
Email: alex24.88@mail.ru
Rússia, Krasnodar