Morphological Evaluation of the Tissue Reaction to Subcutaneous Implantation of Decellularized Matrices
- Authors: Sotnichenko A.S.1, Nakokhov R.Z.1, Gubareva E.A.1, Kuevda E.V.1, Gumenyuk I.S.1
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Affiliations:
- Kuban State Medical University
- Issue: Vol 166, No 2 (2018)
- Pages: 287-292
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240974
- DOI: https://doi.org/10.1007/s10517-018-4334-0
- ID: 240974
Cite item
Abstract
Based on the data of morphological analysis, we performed histological evaluation of rat tissue reaction to subcutaneous implantation of decellularized matrices of intrathoracic organs and tissues. Cell composition of the inflammatory infiltrate was analyzed, and the dynamics of macrophage and T and B lymphocyte content was assessed on days 7 and 14 of the experiment. It was found that the reaction to implantation depended not only on the quality of decellularization and efficiency of removal of antigen molecules, but also on the original histological structure and quality of preimplantation processing of the transplant.
About the authors
A. S. Sotnichenko
Kuban State Medical University
Author for correspondence.
Email: alex24.88@mail.ru
Russian Federation, Krasnodar
R. Z. Nakokhov
Kuban State Medical University
Email: alex24.88@mail.ru
Russian Federation, Krasnodar
E. A. Gubareva
Kuban State Medical University
Email: alex24.88@mail.ru
Russian Federation, Krasnodar
E. V. Kuevda
Kuban State Medical University
Email: alex24.88@mail.ru
Russian Federation, Krasnodar
I. S. Gumenyuk
Kuban State Medical University
Email: alex24.88@mail.ru
Russian Federation, Krasnodar