Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia
- Autores: Dzhalilova D.1, Diatroptov M.1, Tsvetkov I.1, Makarova O.1, Kuznetsov S.2
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Afiliações:
- Research Institute of Human Morphology
- I. M. Sechenov First Moscow State Medical University
- Edição: Volume 165, Nº 6 (2018)
- Páginas: 781-785
- Seção: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/240748
- DOI: https://doi.org/10.1007/s10517-018-4264-x
- ID: 240748
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Resumo
We studied the expression of Hif-1α, Nf-κb, and Vegf genes in the liver and serum levels of HIF-1α, erythropoietin, VEGF, TGF-β, 8-isoprostane, and corticosterone in Wistar rats with different resistance to hypoxia in 5 and 90 min after acute exposure to hypobaric hypoxia. In 5 min after hypoxic exposure, Hif-1α expression in the liver and serum levels of erythropoietin, VEGF, and TGF-β in high-resistant rats were higher than in low-resistant animals. In highresistant rats, the increment in expression of Nf-κb gene responsible for the control over the inflammatory processes was more pronounced than in low-resistant animals. In 90 min after hypoxic exposure, the serum levels of HIF-1α, erythropoietin, VEGF, and TGF-β returned to normal in high-resistant rats, while in low-resistant animals, an increase in 8-isoprostane and TGF-β concentrations was observed. The rats with different resistance to hypoxia were characterized by different changes in biomolecular parameters determining predilection to inflammatory diseases.
Sobre autores
D. Dzhalilova
Research Institute of Human Morphology
Autor responsável pela correspondência
Email: juliajal93@mail.ru
Rússia, Moscow
M. Diatroptov
Research Institute of Human Morphology
Email: juliajal93@mail.ru
Rússia, Moscow
I. Tsvetkov
Research Institute of Human Morphology
Email: juliajal93@mail.ru
Rússia, Moscow
O. Makarova
Research Institute of Human Morphology
Email: juliajal93@mail.ru
Rússia, Moscow
S. Kuznetsov
I. M. Sechenov First Moscow State Medical University
Email: juliajal93@mail.ru
Rússia, Moscow