Polymorphism of Oprm1 Gene and Its Association with Manifestations of N-(1-Phenethyl-4-Piperidyl)Propionanilide Intoxication in Rats
- Authors: Varlamova O.V.1, Babkin A.V.1, Berdinskikh I.S.1, Nazarov G.V.1, Nikiforov A.S.1, Bykov V.N.1, Ivanov M.B.2
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Affiliations:
- State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Institute of Toxicology, Federal Medical-Biological Agency of Russia
- Issue: Vol 165, No 1 (2018)
- Pages: 72-74
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239987
- DOI: https://doi.org/10.1007/s10517-018-4102-1
- ID: 239987
Cite item
Abstract
We studied association of Oprm1 gene polymorphisms with signs of N-(1-phenethyl-4-piperidyl)propionanilide intoxication in rats. It was found that the rate of intoxication in laboratory animals depends on genetic features. A polymorphic variant rs105312806 of Oprm1 gene can be a possible marker of animal sensitivity to opioid receptor agonists. This hypothesis was supported by differences in the rats of intoxication signs such as time to lateral posture and sleep duration in homozygous rats carrying different alleles. In rats with AA genotype, the time to lateral posture was shorter by 1.3 times and sleep duration was longer by 3.5 times than in carriers of GG genotype.
About the authors
O. V. Varlamova
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Russian Federation, Moscow
A. V. Babkin
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Russian Federation, Moscow
I. S. Berdinskikh
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Russian Federation, Moscow
G. V. Nazarov
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Russian Federation, Moscow
A. S. Nikiforov
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Author for correspondence.
Email: nikiforov2004@mail.ru
Russian Federation, Moscow
V. N. Bykov
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Russian Federation, Moscow
M. B. Ivanov
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: nikiforov2004@mail.ru
Russian Federation, St. Petersburg