Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia
- Autores: Povarova O.1, Balatsky A.2, Gusakov V.1, Medvedev O.1
-
Afiliações:
- Faculty of Fundamental Medicine
- Medical Research and Educational Center, M. V. Lomonosov Moscow State University
- Edição: Volume 165, Nº 1 (2018)
- Páginas: 69-71
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239983
- DOI: https://doi.org/10.1007/s10517-018-4101-2
- ID: 239983
Citar
Resumo
The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral artery in the left hemisphere. Ischemia enhanced expression of mRNA of UbiAd1 gene in both cerebral hemispheres, but the effect was significant only in the contralateral one. The study revealed no effect of intraperitoneal injection of coenzyme Q10 (30 mg/kg) on ischemia-produced elevation of mRNA of UbiAd1 gene. Further studies are needed to assess possible neuroprotective effects of antioxidant coenzyme Q10.
Sobre autores
O. Povarova
Faculty of Fundamental Medicine
Autor responsável pela correspondência
Email: oxpovarova@gmail.com
Rússia, Moscow
A. Balatsky
Medical Research and Educational Center, M. V. Lomonosov Moscow State University
Email: oxpovarova@gmail.com
Rússia, Moscow
V. Gusakov
Faculty of Fundamental Medicine
Email: oxpovarova@gmail.com
Rússia, Moscow
O. Medvedev
Faculty of Fundamental Medicine
Email: oxpovarova@gmail.com
Rússia, Moscow