Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia
- Authors: Povarova O.V.1, Balatsky A.V.2, Gusakov V.S.1, Medvedev O.S.1
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Affiliations:
- Faculty of Fundamental Medicine
- Medical Research and Educational Center, M. V. Lomonosov Moscow State University
- Issue: Vol 165, No 1 (2018)
- Pages: 69-71
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239983
- DOI: https://doi.org/10.1007/s10517-018-4101-2
- ID: 239983
Cite item
Abstract
The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral artery in the left hemisphere. Ischemia enhanced expression of mRNA of UbiAd1 gene in both cerebral hemispheres, but the effect was significant only in the contralateral one. The study revealed no effect of intraperitoneal injection of coenzyme Q10 (30 mg/kg) on ischemia-produced elevation of mRNA of UbiAd1 gene. Further studies are needed to assess possible neuroprotective effects of antioxidant coenzyme Q10.
About the authors
O. V. Povarova
Faculty of Fundamental Medicine
Author for correspondence.
Email: oxpovarova@gmail.com
Russian Federation, Moscow
A. V. Balatsky
Medical Research and Educational Center, M. V. Lomonosov Moscow State University
Email: oxpovarova@gmail.com
Russian Federation, Moscow
V. S. Gusakov
Faculty of Fundamental Medicine
Email: oxpovarova@gmail.com
Russian Federation, Moscow
O. S. Medvedev
Faculty of Fundamental Medicine
Email: oxpovarova@gmail.com
Russian Federation, Moscow