Correction of Cholinergic Abnormalities in Mnestic Processes with Diterpene Alkaloid Songorine

Yu. V. Nesterova; T. N. Povet’eva; N. I. Suslov; G. N. Zyuz’kov; V. V. Zhdanov; Yu. S. Fedorova; P. V. Kul’pin; K. V. Shaposhnikov

doi:10.1007/s10517-018-4087-9

Correction of Cholinergic Abnormalities in Mnestic Processes with Diterpene Alkaloid Songorine

Autores: Nesterova Y.¹, Povet’eva T.¹, Suslov N.¹, Zyuz’kov G.¹, Zhdanov V.¹, Fedorova Y.², Kul’pin P.¹, Shaposhnikov K.¹
Afiliações:
1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
2. Kemerovo State Medical University
Edição: Volume 165, Nº 1 (2018)
Páginas: 10-13
Seção: General Pathology and Pathophysiology
URL: https://journals.rcsi.science/0007-4888/article/view/239934
DOI: https://doi.org/10.1007/s10517-018-4087-9
ID: 239934

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Resumo

Repeated administration of songorine to mice restored mnestic processes impaired by scopolamine treatment, which manifested in improvement of CPAR conditioning and normalization of behavioral activity throughtout the observation period. This thearpeutical effect surpassed that of pyracetam used as the reference drug.