Correction of Cholinergic Abnormalities in Mnestic Processes with Diterpene Alkaloid Songorine
- Authors: Nesterova Y.V.1, Povet’eva T.N.1, Suslov N.I.1, Zyuz’kov G.N.1, Zhdanov V.V.1, Fedorova Y.S.2, Kul’pin P.V.1, Shaposhnikov K.V.1
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
- Kemerovo State Medical University
- Issue: Vol 165, No 1 (2018)
- Pages: 10-13
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239934
- DOI: https://doi.org/10.1007/s10517-018-4087-9
- ID: 239934
Cite item
Abstract
Repeated administration of songorine to mice restored mnestic processes impaired by scopolamine treatment, which manifested in improvement of CPAR conditioning and normalization of behavioral activity throughtout the observation period. This thearpeutical effect surpassed that of pyracetam used as the reference drug.
About the authors
Yu. V. Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Author for correspondence.
Email: nes-yulia@yandex.ru
Russian Federation, Tomsk
T. N. Povet’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: nes-yulia@yandex.ru
Russian Federation, Tomsk
N. I. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: nes-yulia@yandex.ru
Russian Federation, Tomsk
G. N. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: nes-yulia@yandex.ru
Russian Federation, Tomsk
V. V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: nes-yulia@yandex.ru
Russian Federation, Tomsk
Yu. S. Fedorova
Kemerovo State Medical University
Email: nes-yulia@yandex.ru
Russian Federation, Kemerovo
P. V. Kul’pin
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: nes-yulia@yandex.ru
Russian Federation, Tomsk
K. V. Shaposhnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: nes-yulia@yandex.ru
Russian Federation, Tomsk