Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography
- Autores: Rogozinskaya E.1, Lyapina M.1
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Afiliações:
- Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University
- Edição: Volume 164, Nº 2 (2017)
- Páginas: 170-172
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239450
- DOI: https://doi.org/10.1007/s10517-017-3950-4
- ID: 239450
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Resumo
Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank demonstrated the maximal anticoagulation potency.
Sobre autores
E. Rogozinskaya
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University
Autor responsável pela correspondência
Email: elinamiss007@mail.ru
Rússia, Moscow
M. Lyapina
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University
Email: elinamiss007@mail.ru
Rússia, Moscow