Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death
- Autores: Ivanova A.1, Maksimov V.1,2, Ivanoshchuk D.1,3,4, Orlov P.1,3,4, Novoselov V.2,5, Savchenko S.2,5, Voevoda M.1,3,4
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Afiliações:
- Research Institute of Therapy and Preventive Medicine
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Novosibirsk Regional Clinical Bureau of Forensic Medicine
- Edição: Volume 163, Nº 1 (2017)
- Páginas: 73-77
- Seção: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/238655
- DOI: https://doi.org/10.1007/s10517-017-3741-y
- ID: 238655
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Resumo
We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rs1805124 and rs13376333 genotypes and alleles. In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p=0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p=0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p=0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group.
Sobre autores
A. Ivanova
Research Institute of Therapy and Preventive Medicine
Autor responsável pela correspondência
Email: ivanova_a_a@mail.ru
Rússia, Novosibirsk
V. Maksimov
Research Institute of Therapy and Preventive Medicine; Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: ivanova_a_a@mail.ru
Rússia, Novosibirsk; Novosibirsk
D. Ivanoshchuk
Research Institute of Therapy and Preventive Medicine; Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: ivanova_a_a@mail.ru
Rússia, Novosibirsk; Novosibirsk; Novosibirsk
P. Orlov
Research Institute of Therapy and Preventive Medicine; Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: ivanova_a_a@mail.ru
Rússia, Novosibirsk; Novosibirsk; Novosibirsk
V. Novoselov
Novosibirsk State Medical University, Ministry of Health of the Russian Federation; Novosibirsk Regional Clinical Bureau of Forensic Medicine
Email: ivanova_a_a@mail.ru
Rússia, Novosibirsk; Novosibirsk
S. Savchenko
Novosibirsk State Medical University, Ministry of Health of the Russian Federation; Novosibirsk Regional Clinical Bureau of Forensic Medicine
Email: ivanova_a_a@mail.ru
Rússia, Novosibirsk; Novosibirsk
M. Voevoda
Research Institute of Therapy and Preventive Medicine; Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: ivanova_a_a@mail.ru
Rússia, Novosibirsk; Novosibirsk; Novosibirsk
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