Enviar artigo por via de e-mail Endomorphins and β-Endorphin Do Not Affect Heart Tolerance to the Pathogenic Effect of Reperfusion
- Autores: Mukhomedzyanov A.1, Maslov L.1, Tsibulnikov S.1, Pei J.2
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Afiliações:
- Research Institute of Cardiology
- Fourth Military Medical University
- Edição: Volume 162, Nº 1 (2016)
- Páginas: 23-26
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237869
- DOI: https://doi.org/10.1007/s10517-016-3535-7
- ID: 237869
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Somente assinantes
Resumo
Selective agonists of μ1- and μ2-opioid receptors endomorphin-2 and endomorphin-1 injected intravenously in a dose of 4500 nmol/kg in 5 min before coronary blood flow resumption had no effect on cardiac reperfusion damage. Consequently, μ1- and μ2-opioid receptors are not involved in the regulation of heart tolerance to reperfusion injury. Nonselective opioid receptor agonist β-endorphin (100 nmol/kg) also did not affect heart tolerance to the pathogenic effect of reperfusion.
Sobre autores
A. Mukhomedzyanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Rússia, Tomsk
L. Maslov
Research Institute of Cardiology
Autor responsável pela correspondência
Email: maslov@cardio-tomsk.ru
Rússia, Tomsk
S. Tsibulnikov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Rússia, Tomsk
J. Pei
Fourth Military Medical University
Email: maslov@cardio-tomsk.ru
República Popular da China, Xi’an, Shaanxi Province
