Email this article Endomorphins and β-Endorphin Do Not Affect Heart Tolerance to the Pathogenic Effect of Reperfusion
- Authors: Mukhomedzyanov A.V.1, Maslov L.N.1, Tsibulnikov S.Y.1, Pei J.M.2
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Affiliations:
- Research Institute of Cardiology
- Fourth Military Medical University
- Issue: Vol 162, No 1 (2016)
- Pages: 23-26
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237869
- DOI: https://doi.org/10.1007/s10517-016-3535-7
- ID: 237869
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Abstract
Selective agonists of μ1- and μ2-opioid receptors endomorphin-2 and endomorphin-1 injected intravenously in a dose of 4500 nmol/kg in 5 min before coronary blood flow resumption had no effect on cardiac reperfusion damage. Consequently, μ1- and μ2-opioid receptors are not involved in the regulation of heart tolerance to reperfusion injury. Nonselective opioid receptor agonist β-endorphin (100 nmol/kg) also did not affect heart tolerance to the pathogenic effect of reperfusion.
About the authors
A. V. Mukhomedzyanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
L. N. Maslov
Research Institute of Cardiology
Author for correspondence.
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
S. Yu. Tsibulnikov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
J. M. Pei
Fourth Military Medical University
Email: maslov@cardio-tomsk.ru
China, Xi’an, Shaanxi Province
