Enviar artigo por via de e-mail Comparative Evaluation of β-Catenin and E-Cadherin Expression in Liquid Aspiration Biopsy Specimens of Thyroid Nodules
- Autores: Isaeva A.1,2, Zima A.1,3, Saprina T.1, Kasoyan K.4, Popov O.1, Brynova O.5, Berezkina I.1, Vasil’eva O.1, Ryazantseva N.6,7, Shabalova I.4, Litvinova L.3, Pak Y.8, Novitskii V.1
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Afiliações:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Tomsk Research Institute of Oncology
- I. Kant Baltic Federal University
- Russian Medical Academy of Postgraduate Education
- Moscow Municipal Oncological Hospital No. 62
- V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
- Siberian Federal University
- Tomsk Regional Clinical Hospital
- Edição: Volume 161, Nº 2 (2016)
- Páginas: 288-291
- Seção: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/237343
- DOI: https://doi.org/10.1007/s10517-016-3397-z
- ID: 237343
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Resumo
We compared the results of gene molecular and immunocytochemical studies of β-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/β-catenin complex leading to switching from adhesion function of β-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin–β-catenin interactions in the mechanisms of malignant transformation of follicular epithelium.
Sobre autores
A. Isaeva
Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Research Institute of Oncology
Autor responsável pela correspondência
Email: seneann@mail.ru
Rússia, Moscow; Tomsk
A. Zima
Siberian State Medical University, Ministry of Health of the Russian Federation; I. Kant Baltic Federal University
Email: seneann@mail.ru
Rússia, Moscow; Kaliningrad
T. Saprina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Rússia, Moscow
K. Kasoyan
Russian Medical Academy of Postgraduate Education
Email: seneann@mail.ru
Rússia, Moscow
O. Popov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Rússia, Moscow
O. Brynova
Moscow Municipal Oncological Hospital No. 62
Email: seneann@mail.ru
Rússia, Moscow
I. Berezkina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Rússia, Moscow
O. Vasil’eva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Rússia, Moscow
N. Ryazantseva
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Siberian Federal University
Email: seneann@mail.ru
Rússia, Krasnoyarsk; Krasnoyarsk
I. Shabalova
Russian Medical Academy of Postgraduate Education
Email: seneann@mail.ru
Rússia, Moscow
L. Litvinova
I. Kant Baltic Federal University
Email: seneann@mail.ru
Rússia, Kaliningrad
Yu. Pak
Tomsk Regional Clinical Hospital
Email: seneann@mail.ru
Rússia, Tomsk
V. Novitskii
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Rússia, Moscow
