Email this article Comparative Evaluation of β-Catenin and E-Cadherin Expression in Liquid Aspiration Biopsy Specimens of Thyroid Nodules
- Authors: Isaeva A.V.1,2, Zima A.P.1,3, Saprina T.V.1, Kasoyan K.T.4, Popov O.S.1, Brynova O.V.5, Berezkina I.S.1, Vasil’eva O.A.1, Ryazantseva N.V.6,7, Shabalova I.P.4, Litvinova L.S.3, Pak Y.D.8, Novitskii V.V.1
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Affiliations:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Tomsk Research Institute of Oncology
- I. Kant Baltic Federal University
- Russian Medical Academy of Postgraduate Education
- Moscow Municipal Oncological Hospital No. 62
- V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
- Siberian Federal University
- Tomsk Regional Clinical Hospital
- Issue: Vol 161, No 2 (2016)
- Pages: 288-291
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/237343
- DOI: https://doi.org/10.1007/s10517-016-3397-z
- ID: 237343
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Abstract
We compared the results of gene molecular and immunocytochemical studies of β-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/β-catenin complex leading to switching from adhesion function of β-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin–β-catenin interactions in the mechanisms of malignant transformation of follicular epithelium.
About the authors
A. V. Isaeva
Siberian State Medical University, Ministry of Health of the Russian Federation; Tomsk Research Institute of Oncology
Author for correspondence.
Email: seneann@mail.ru
Russian Federation, Moscow; Tomsk
A. P. Zima
Siberian State Medical University, Ministry of Health of the Russian Federation; I. Kant Baltic Federal University
Email: seneann@mail.ru
Russian Federation, Moscow; Kaliningrad
T. V. Saprina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Russian Federation, Moscow
K. T. Kasoyan
Russian Medical Academy of Postgraduate Education
Email: seneann@mail.ru
Russian Federation, Moscow
O. S. Popov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Russian Federation, Moscow
O. V. Brynova
Moscow Municipal Oncological Hospital No. 62
Email: seneann@mail.ru
Russian Federation, Moscow
I. S. Berezkina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Russian Federation, Moscow
O. A. Vasil’eva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Russian Federation, Moscow
N. V. Ryazantseva
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Siberian Federal University
Email: seneann@mail.ru
Russian Federation, Krasnoyarsk; Krasnoyarsk
I. P. Shabalova
Russian Medical Academy of Postgraduate Education
Email: seneann@mail.ru
Russian Federation, Moscow
L. S. Litvinova
I. Kant Baltic Federal University
Email: seneann@mail.ru
Russian Federation, Kaliningrad
Yu. D. Pak
Tomsk Regional Clinical Hospital
Email: seneann@mail.ru
Russian Federation, Tomsk
V. V. Novitskii
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: seneann@mail.ru
Russian Federation, Moscow
