Effect of Antidepressants on Immunological Reactivity in ASC Mice with Genetically Determined Depression-Like State
- Autores: Gevorgyan M.1, Idova G.1, Al’perina E.1, Tikhonova M.1,2, Kulikov A.1
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Afiliações:
- Research Institute of Physiology and Fundamental Medicine
- Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Edição: Volume 161, Nº 2 (2016)
- Páginas: 266-269
- Seção: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/237325
- DOI: https://doi.org/10.1007/s10517-016-3392-4
- ID: 237325
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Resumo
The effect of chronic treatment with antidepressant drugs fluoxetine (20 mg/kg) and imipramine (25 mg/kg) on the number of antibody-producing cells and the main T cell subpopulations in ASC mice characterized by genetic predisposition to depression-like states was studied at the peak of the SE-induced immune response (5×108). Fluoxetine produced an immunostimulatory effect manifested in an increase in the relative and absolute number of IgM antibody-producing cells in the spleen and index of immunoreactivity (CD4/CD8). Administration of fl uoxetine to parental mouse strains without depression (CBA and AKR) had no effect (CBA) or reduced the immune response. The CD4/CD8 ratio did not increase under these conditions. Imipramine was ineffective in the correction of immune reactions in a depression-like state.
Sobre autores
M. Gevorgyan
Research Institute of Physiology and Fundamental Medicine
Autor responsável pela correspondência
Email: gevorgyanmm@ngs.ru
Rússia, Novosibirsk
G. Idova
Research Institute of Physiology and Fundamental Medicine
Email: gevorgyanmm@ngs.ru
Rússia, Novosibirsk
E. Al’perina
Research Institute of Physiology and Fundamental Medicine
Email: gevorgyanmm@ngs.ru
Rússia, Novosibirsk
M. Tikhonova
Research Institute of Physiology and Fundamental Medicine; Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: gevorgyanmm@ngs.ru
Rússia, Novosibirsk; Novosibirsk
A. Kulikov
Research Institute of Physiology and Fundamental Medicine
Email: gevorgyanmm@ngs.ru
Rússia, Novosibirsk