Effect of Antidepressants on Immunological Reactivity in ASC Mice with Genetically Determined Depression-Like State
- Authors: Gevorgyan M.M.1, Idova G.V.1, Al’perina E.L.1, Tikhonova M.A.1,2, Kulikov A.V.1
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Affiliations:
- Research Institute of Physiology and Fundamental Medicine
- Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 161, No 2 (2016)
- Pages: 266-269
- Section: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/237325
- DOI: https://doi.org/10.1007/s10517-016-3392-4
- ID: 237325
Cite item
Abstract
The effect of chronic treatment with antidepressant drugs fluoxetine (20 mg/kg) and imipramine (25 mg/kg) on the number of antibody-producing cells and the main T cell subpopulations in ASC mice characterized by genetic predisposition to depression-like states was studied at the peak of the SE-induced immune response (5×108). Fluoxetine produced an immunostimulatory effect manifested in an increase in the relative and absolute number of IgM antibody-producing cells in the spleen and index of immunoreactivity (CD4/CD8). Administration of fl uoxetine to parental mouse strains without depression (CBA and AKR) had no effect (CBA) or reduced the immune response. The CD4/CD8 ratio did not increase under these conditions. Imipramine was ineffective in the correction of immune reactions in a depression-like state.
About the authors
M. M. Gevorgyan
Research Institute of Physiology and Fundamental Medicine
Author for correspondence.
Email: gevorgyanmm@ngs.ru
Russian Federation, Novosibirsk
G. V. Idova
Research Institute of Physiology and Fundamental Medicine
Email: gevorgyanmm@ngs.ru
Russian Federation, Novosibirsk
E. L. Al’perina
Research Institute of Physiology and Fundamental Medicine
Email: gevorgyanmm@ngs.ru
Russian Federation, Novosibirsk
M. A. Tikhonova
Research Institute of Physiology and Fundamental Medicine; Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: gevorgyanmm@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
A. V. Kulikov
Research Institute of Physiology and Fundamental Medicine
Email: gevorgyanmm@ngs.ru
Russian Federation, Novosibirsk