Role of β-Adrenoceptors and L-Type Ca2+-Channels in the Mechanism of Reperfusion-Induced Heart Injury
- Authors: Lishmanov Y.B.1, Maslov L.N.1, Mukhomedzyanov A.V.1
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Affiliations:
- Research Institute of Cardiology
- Issue: Vol 161, No 1 (2016)
- Pages: 20-23
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237056
- DOI: https://doi.org/10.1007/s10517-016-3335-0
- ID: 237056
Cite item
Abstract
We studied the effects of β-adrenoceptor antagonists propranolol and nadolol and L-type Ca2+-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of β-adrenoceptors and opening of L-type Ca2+-channels promote the development of cardiac reperfusion injury, while blockage of β-adrenoceptors and/or L-type Ca2+-channels prevents reoxygenation-induced myocardial injury. Propranolol, nadolol, and verapamil can produce infraction-limiting effects after onset of ischemic heart injury.
About the authors
Yu. B. Lishmanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
L. N. Maslov
Research Institute of Cardiology
Author for correspondence.
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
A. V. Mukhomedzyanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk