p53- and Caspase-3-Independent Mechanism of Acetaminophen Effect on Human Neural Cells
- Autores: Aleksandrova A.1, Senyavina N.1, Maltseva D.1, Khutornenko A.1, Sakharov D.1
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Afiliações:
- BioClinicum Research and Development Complex
- Edição: Volume 160, Nº 6 (2016)
- Páginas: 763-766
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236933
- DOI: https://doi.org/10.1007/s10517-016-3304-7
- ID: 236933
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Resumo
Acetaminophen in a concentration of 5 mM increased the expression of JNK, HIF1A (hypoxiainduced factor), and CASP3, which indicated development of oxidative stress and apoptotic cell death. Acetaminophen in a concentration of 10 mM did not induce expression of HIF1A and CASP3, but reduced expression of chaperone HSP90, which attested to activation of a caspase-3-independent mechanism of cell death. The methods of preventing acetaminophen intoxication are discussed.
Sobre autores
A. Aleksandrova
BioClinicum Research and Development Complex
Autor responsável pela correspondência
Email: a.aleksandrova@bioclinicum.com
Rússia, Moscow
N. Senyavina
BioClinicum Research and Development Complex
Email: a.aleksandrova@bioclinicum.com
Rússia, Moscow
D. Maltseva
BioClinicum Research and Development Complex
Email: a.aleksandrova@bioclinicum.com
Rússia, Moscow
A. Khutornenko
BioClinicum Research and Development Complex
Email: a.aleksandrova@bioclinicum.com
Rússia, Moscow
D. Sakharov
BioClinicum Research and Development Complex
Email: a.aleksandrova@bioclinicum.com
Rússia, Moscow
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