p53- and Caspase-3-Independent Mechanism of Acetaminophen Effect on Human Neural Cells

A. V. Aleksandrova; N. V. Senyavina; D. V. Maltseva; A. A. Khutornenko; D. A. Sakharov

doi:10.1007/s10517-016-3304-7

p53- and Caspase-3-Independent Mechanism of Acetaminophen Effect on Human Neural Cells

Authors: Aleksandrova A.V.¹, Senyavina N.V.¹, Maltseva D.V.¹, Khutornenko A.A.¹, Sakharov D.A.¹
Affiliations:
1. BioClinicum Research and Development Complex
Issue: Vol 160, No 6 (2016)
Pages: 763-766
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/236933
DOI: https://doi.org/10.1007/s10517-016-3304-7
ID: 236933

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Abstract

Acetaminophen in a concentration of 5 mM increased the expression of JNK, HIF1A (hypoxiainduced factor), and CASP3, which indicated development of oxidative stress and apoptotic cell death. Acetaminophen in a concentration of 10 mM did not induce expression of HIF1A and CASP3, but reduced expression of chaperone HSP90, which attested to activation of a caspase-3-independent mechanism of cell death. The methods of preventing acetaminophen intoxication are discussed.