Psychotropic Activity of New Fluorinated Derivatives of Tetrahydrocarbasoles
- Autores: Nikolaeva N.1, Sokolov V.1, Aksinenko A.1, Ovchinnikov R.1, Bachurin S.1, Kinzirskii A.1
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Afiliações:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Edição: Volume 160, Nº 4 (2016)
- Páginas: 455-458
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236731
- DOI: https://doi.org/10.1007/s10517-016-3195-7
- ID: 236731
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Resumo
Psychotropic properties of CA-7043× and CA-7050×, new fluorinated derivatives of tetrahydrocarbasoles, were examined on outbred CD1 mice and transgenic 5×FAD mice with Alzheimer disease. Both agents exerted cognitive-stimulating and anxiolytic effects in a dose of 5 mg/kg. In the new cage test, they retarded extinction of orientation and exploratory behavior. CA-7043× produced an anxiolytic effect on CD1 mice assessed in the open-field test and exerted cognitive-stimulating action in the new location test. In the same tests, CA-7050× demonstrated the cognitive-stimulating and anxiolytic effects on transgenic 5×FAD mice.
Sobre autores
N. Nikolaeva
Institute of Physiologically Active Substances, Russian Academy of Sciences
Autor responsável pela correspondência
Email: nikolaevans@bk.ru
Rússia, Moscow Region, Chernogolovka
V. Sokolov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Rússia, Moscow Region, Chernogolovka
A. Aksinenko
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Rússia, Moscow Region, Chernogolovka
R. Ovchinnikov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Rússia, Moscow Region, Chernogolovka
S. Bachurin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Rússia, Moscow Region, Chernogolovka
A. Kinzirskii
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Rússia, Moscow Region, Chernogolovka