Psychotropic Activity of New Fluorinated Derivatives of Tetrahydrocarbasoles
- Authors: Nikolaeva N.S.1, Sokolov V.B.1, Aksinenko A.Y.1, Ovchinnikov R.K.1, Bachurin S.O.1, Kinzirskii A.S.1
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Affiliations:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Issue: Vol 160, No 4 (2016)
- Pages: 455-458
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236731
- DOI: https://doi.org/10.1007/s10517-016-3195-7
- ID: 236731
Cite item
Abstract
Psychotropic properties of CA-7043× and CA-7050×, new fluorinated derivatives of tetrahydrocarbasoles, were examined on outbred CD1 mice and transgenic 5×FAD mice with Alzheimer disease. Both agents exerted cognitive-stimulating and anxiolytic effects in a dose of 5 mg/kg. In the new cage test, they retarded extinction of orientation and exploratory behavior. CA-7043× produced an anxiolytic effect on CD1 mice assessed in the open-field test and exerted cognitive-stimulating action in the new location test. In the same tests, CA-7050× demonstrated the cognitive-stimulating and anxiolytic effects on transgenic 5×FAD mice.
About the authors
N. S. Nikolaeva
Institute of Physiologically Active Substances, Russian Academy of Sciences
Author for correspondence.
Email: nikolaevans@bk.ru
Russian Federation, Moscow Region, Chernogolovka
V. B. Sokolov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Moscow Region, Chernogolovka
A. Yu. Aksinenko
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Moscow Region, Chernogolovka
R. K. Ovchinnikov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Moscow Region, Chernogolovka
S. O. Bachurin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Moscow Region, Chernogolovka
A. S. Kinzirskii
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Moscow Region, Chernogolovka