Assessment of Expression of Genes Coding GABAA Receptors during Chronic and Acute Intoxication of Laboratory Rats with Ethanol
- Autores: Osechkina N.1, Ivanov M.1, Nazarov G.2, Batotsyrenova E.1, Lapina N.1, Babkin A.2, Berdinskikh I.2, Melekhova A.1, Voitsekhovich K.1, Lisitskii D.1, Kashina T.1
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Afiliações:
- Institute of Toxicology, Federal Medical-Biological Agency of Russia
- Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation
- Edição: Volume 160, Nº 4 (2016)
- Páginas: 452-454
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236730
- DOI: https://doi.org/10.1007/s10517-016-3194-8
- ID: 236730
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Resumo
Expression of genes encoding the individual subunits of ionotropic GABAA receptor was assessed after acute and chronic intoxication of rats with ethanol. The chronic 1-month-long exposure to ethanol signifi cantly decreased (by 38%) expression of Gabrb1 gene in the hippocampus. Acute exposure to ethanol elevated expression of genes Gabrb1 (by 1.7 times), Gabra1 (by 3.8 times), and Gabra4 (by 6.5 times), although it diminished expression of Gabra2 gene by 1.4 times. In preliminarily alcoholized rats, acute intoxication with ethanol enhanced expression of genes Gabrb1 and Gabra5 by 1.7 and 8.7 times, respectively. There was neither acute nor chronic effect of ethanol on expression of gene Gabra3.
Sobre autores
N. Osechkina
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Autor responsável pela correspondência
Email: dunats@rambler.ru
Rússia, St Petersburg
M. Ivanov
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Rússia, St Petersburg
G. Nazarov
Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation
Email: dunats@rambler.ru
Rússia, St. Petersburg
E. Batotsyrenova
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Rússia, St Petersburg
N. Lapina
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Rússia, St Petersburg
A. Babkin
Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation
Email: dunats@rambler.ru
Rússia, St. Petersburg
I. Berdinskikh
Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation
Email: dunats@rambler.ru
Rússia, St. Petersburg
A. Melekhova
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Rússia, St Petersburg
K. Voitsekhovich
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Rússia, St Petersburg
D. Lisitskii
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Rússia, St Petersburg
T. Kashina
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Rússia, St Petersburg