Assessment of Expression of Genes Coding GABAA Receptors during Chronic and Acute Intoxication of Laboratory Rats with Ethanol
- Authors: Osechkina N.S.1, Ivanov M.B.1, Nazarov G.V.2, Batotsyrenova E.G.1, Lapina N.V.1, Babkin A.V.2, Berdinskikh I.S.2, Melekhova A.S.1, Voitsekhovich K.O.1, Lisitskii D.S.1, Kashina T.V.1
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Affiliations:
- Institute of Toxicology, Federal Medical-Biological Agency of Russia
- Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation
- Issue: Vol 160, No 4 (2016)
- Pages: 452-454
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236730
- DOI: https://doi.org/10.1007/s10517-016-3194-8
- ID: 236730
Cite item
Abstract
Expression of genes encoding the individual subunits of ionotropic GABAA receptor was assessed after acute and chronic intoxication of rats with ethanol. The chronic 1-month-long exposure to ethanol signifi cantly decreased (by 38%) expression of Gabrb1 gene in the hippocampus. Acute exposure to ethanol elevated expression of genes Gabrb1 (by 1.7 times), Gabra1 (by 3.8 times), and Gabra4 (by 6.5 times), although it diminished expression of Gabra2 gene by 1.4 times. In preliminarily alcoholized rats, acute intoxication with ethanol enhanced expression of genes Gabrb1 and Gabra5 by 1.7 and 8.7 times, respectively. There was neither acute nor chronic effect of ethanol on expression of gene Gabra3.
About the authors
N. S. Osechkina
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Author for correspondence.
Email: dunats@rambler.ru
Russian Federation, St Petersburg
M. B. Ivanov
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Russian Federation, St Petersburg
G. V. Nazarov
Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation
Email: dunats@rambler.ru
Russian Federation, St. Petersburg
E. G. Batotsyrenova
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Russian Federation, St Petersburg
N. V. Lapina
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Russian Federation, St Petersburg
A. V. Babkin
Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation
Email: dunats@rambler.ru
Russian Federation, St. Petersburg
I. S. Berdinskikh
Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation
Email: dunats@rambler.ru
Russian Federation, St. Petersburg
A. S. Melekhova
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Russian Federation, St Petersburg
K. O. Voitsekhovich
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Russian Federation, St Petersburg
D. S. Lisitskii
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Russian Federation, St Petersburg
T. V. Kashina
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: dunats@rambler.ru
Russian Federation, St Petersburg