Enviar artigo por via de e-mail Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats
- Autores: Karpova M.1, Kuznetsova L.1, Zin’kovskii K.2, Klishina N.1
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Afiliações:
- Research Institute of General Pathology and Pathophysiology
- Department of Psychiatry, Addiction Medicine, and Medical Psychology, Tver’ State Medical Academy, Ministry of Health of the Russian Federation
- Edição: Volume 160, Nº 4 (2016)
- Páginas: 429-431
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236724
- DOI: https://doi.org/10.1007/s10517-016-3188-6
- ID: 236724
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Resumo
We studied anticonvulsant effects of combined treatment with citicoline, a nootropic substance with neuroregenerative and neuroprotective activities, and valproate, an antiepileptic agent widely used in the treatment of epilepsy, on the model of pentylenetetrazole-induced (75 mg/kg, intraperitoneally) acute generalized convulsions in male Wistar rats. Combined treatment with citicoline and valproate in minimum effective doses (70 and 300 mg/kg, respectively) potentiated the anticonvulsant properties of both agents.
Sobre autores
M. Karpova
Research Institute of General Pathology and Pathophysiology
Autor responsável pela correspondência
Email: karpovamn@gmail.com
Rússia, Moscow
L. Kuznetsova
Research Institute of General Pathology and Pathophysiology
Email: karpovamn@gmail.com
Rússia, Moscow
K. Zin’kovskii
Department of Psychiatry, Addiction Medicine, and Medical Psychology, Tver’ State Medical Academy, Ministry of Health of the Russian Federation
Email: karpovamn@gmail.com
Rússia, Tver’
N. Klishina
Research Institute of General Pathology and Pathophysiology
Email: karpovamn@gmail.com
Rússia, Moscow
