Email this article Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats
- Authors: Karpova M.N.1, Kuznetsova L.V.1, Zin’kovskii K.A.2, Klishina N.V.1
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Affiliations:
- Research Institute of General Pathology and Pathophysiology
- Department of Psychiatry, Addiction Medicine, and Medical Psychology, Tver’ State Medical Academy, Ministry of Health of the Russian Federation
- Issue: Vol 160, No 4 (2016)
- Pages: 429-431
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236724
- DOI: https://doi.org/10.1007/s10517-016-3188-6
- ID: 236724
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Abstract
We studied anticonvulsant effects of combined treatment with citicoline, a nootropic substance with neuroregenerative and neuroprotective activities, and valproate, an antiepileptic agent widely used in the treatment of epilepsy, on the model of pentylenetetrazole-induced (75 mg/kg, intraperitoneally) acute generalized convulsions in male Wistar rats. Combined treatment with citicoline and valproate in minimum effective doses (70 and 300 mg/kg, respectively) potentiated the anticonvulsant properties of both agents.
About the authors
M. N. Karpova
Research Institute of General Pathology and Pathophysiology
Author for correspondence.
Email: karpovamn@gmail.com
Russian Federation, Moscow
L. V. Kuznetsova
Research Institute of General Pathology and Pathophysiology
Email: karpovamn@gmail.com
Russian Federation, Moscow
K. A. Zin’kovskii
Department of Psychiatry, Addiction Medicine, and Medical Psychology, Tver’ State Medical Academy, Ministry of Health of the Russian Federation
Email: karpovamn@gmail.com
Russian Federation, Tver’
N. V. Klishina
Research Institute of General Pathology and Pathophysiology
Email: karpovamn@gmail.com
Russian Federation, Moscow
