Formation of Alcohol Motivation in Monkeys (Macaca mulatta) Kept in Isolation
- Авторлар: Shmaliy A.1, Pavlova L.1, Chuguev Y.1, Kolik L.2, Kovalenko V.3, Seredenin S.2, Lapin B.1
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Мекемелер:
- Research Institute of Medical Primatology
- V.V. Zakusov Institute of Pharmacology
- Sochi State University
- Шығарылым: Том 167, № 4 (2019)
- Беттер: 516-520
- Бөлім: Primatology
- URL: https://journals.rcsi.science/0007-4888/article/view/241845
- DOI: https://doi.org/10.1007/s10517-019-04563-4
- ID: 241845
Дәйексөз келтіру
Аннотация
The effects of environmental factors (flavors, different ethanol concentration, alcoholic deprivation, and food reinforcement) on the formation of alcohol motivation was studied in rhesus macaques (Macaca mulatta, n=6). Motivation for alcohol intake was induced in two stages: initiation (sessions 1-160) and formation of motivation (sessions 161-516). Monkeys preferred multifruit flavor and 4% ethanol solution, while ethanol deprivation did not stimulate alcohol consumption. The pronounced individual differences in the pattern of alcohol motivation were revealed: the intake of 4% ethanol solution ranged from 0.21±0.03 to 0.43±0.06 g/kg without food reinforcement and increased from 0.78±0.03 to 1.22±0.09 g/kg with food reinforcement. The results suggest that the proposed method is valid and can be used as an experimental model of alcohol dependence in non-human primates.
Авторлар туралы
A. Shmaliy
Research Institute of Medical Primatology
Хат алмасуға жауапты Автор.
Email: shmaliy.a.v@gmail.com
Ресей, Sochi
L. Pavlova
Research Institute of Medical Primatology
Email: shmaliy.a.v@gmail.com
Ресей, Sochi
Yu. Chuguev
Research Institute of Medical Primatology
Email: shmaliy.a.v@gmail.com
Ресей, Sochi
L. Kolik
V.V. Zakusov Institute of Pharmacology
Email: shmaliy.a.v@gmail.com
Ресей, Moscow
V. Kovalenko
Sochi State University
Email: shmaliy.a.v@gmail.com
Ресей, Sochi
S. Seredenin
V.V. Zakusov Institute of Pharmacology
Email: shmaliy.a.v@gmail.com
Ресей, Moscow
B. Lapin
Research Institute of Medical Primatology
Email: shmaliy.a.v@gmail.com
Ресей, Sochi