Formation of Alcohol Motivation in Monkeys (Macaca mulatta) Kept in Isolation
- 作者: Shmaliy A.1, Pavlova L.1, Chuguev Y.1, Kolik L.2, Kovalenko V.3, Seredenin S.2, Lapin B.1
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隶属关系:
- Research Institute of Medical Primatology
- V.V. Zakusov Institute of Pharmacology
- Sochi State University
- 期: 卷 167, 编号 4 (2019)
- 页面: 516-520
- 栏目: Primatology
- URL: https://journals.rcsi.science/0007-4888/article/view/241845
- DOI: https://doi.org/10.1007/s10517-019-04563-4
- ID: 241845
如何引用文章
详细
The effects of environmental factors (flavors, different ethanol concentration, alcoholic deprivation, and food reinforcement) on the formation of alcohol motivation was studied in rhesus macaques (Macaca mulatta, n=6). Motivation for alcohol intake was induced in two stages: initiation (sessions 1-160) and formation of motivation (sessions 161-516). Monkeys preferred multifruit flavor and 4% ethanol solution, while ethanol deprivation did not stimulate alcohol consumption. The pronounced individual differences in the pattern of alcohol motivation were revealed: the intake of 4% ethanol solution ranged from 0.21±0.03 to 0.43±0.06 g/kg without food reinforcement and increased from 0.78±0.03 to 1.22±0.09 g/kg with food reinforcement. The results suggest that the proposed method is valid and can be used as an experimental model of alcohol dependence in non-human primates.
作者简介
A. Shmaliy
Research Institute of Medical Primatology
编辑信件的主要联系方式.
Email: shmaliy.a.v@gmail.com
俄罗斯联邦, Sochi
L. Pavlova
Research Institute of Medical Primatology
Email: shmaliy.a.v@gmail.com
俄罗斯联邦, Sochi
Yu. Chuguev
Research Institute of Medical Primatology
Email: shmaliy.a.v@gmail.com
俄罗斯联邦, Sochi
L. Kolik
V.V. Zakusov Institute of Pharmacology
Email: shmaliy.a.v@gmail.com
俄罗斯联邦, Moscow
V. Kovalenko
Sochi State University
Email: shmaliy.a.v@gmail.com
俄罗斯联邦, Sochi
S. Seredenin
V.V. Zakusov Institute of Pharmacology
Email: shmaliy.a.v@gmail.com
俄罗斯联邦, Moscow
B. Lapin
Research Institute of Medical Primatology
Email: shmaliy.a.v@gmail.com
俄罗斯联邦, Sochi