Adenylate Cyclase-Associated Protein 1 and Cofilin in Progression of Non-Small Cell Lung Cancer
- Авторлар: Kolegova E.1, Kakurina G.1, Kondakova I.1, Dobrodeev A.1, Kostromitskii D.2, Zhuikova L.1
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Мекемелер:
- Tomsk National Research Medical Center, Russian Academy of Science
- Tomsk Regional Oncology Center
- Шығарылым: Том 167, № 3 (2019)
- Беттер: 393-395
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241737
- DOI: https://doi.org/10.1007/s10517-019-04534-9
- ID: 241737
Дәйексөз келтіру
Аннотация
We studied the expression of mRNA and the level of CAP1 (adenylate cyclase-associated protein 1) and cofilin proteins in the tissues of patients with non-small cell lung cancer. The expression of mRNA and the level of CAP1 in tumor tissue increased during growth of the primary tumor and its metastasis. It was shown that with the growth of the primary tumor, the content of cofilin in the tumor tissue decreases against the background of increased expression of its mRNA; in regional metastasis, the content of cofilin and expression of the corresponding mRNA increased. It was found that increased content of the studied proteins in the tumor tissue increased the risk of metastasis.
Авторлар туралы
E. Kolegova
Tomsk National Research Medical Center, Russian Academy of Science
Хат алмасуға жауапты Автор.
Email: elenakolegova@oncology.tomsk.ru
Ресей, Tomsk
G. Kakurina
Tomsk National Research Medical Center, Russian Academy of Science
Email: elenakolegova@oncology.tomsk.ru
Ресей, Tomsk
I. Kondakova
Tomsk National Research Medical Center, Russian Academy of Science
Email: elenakolegova@oncology.tomsk.ru
Ресей, Tomsk
A. Dobrodeev
Tomsk National Research Medical Center, Russian Academy of Science
Email: elenakolegova@oncology.tomsk.ru
Ресей, Tomsk
D. Kostromitskii
Tomsk Regional Oncology Center
Email: elenakolegova@oncology.tomsk.ru
Ресей, Tomsk
L. Zhuikova
Tomsk National Research Medical Center, Russian Academy of Science
Email: elenakolegova@oncology.tomsk.ru
Ресей, Tomsk