Adenylate Cyclase-Associated Protein 1 and Cofilin in Progression of Non-Small Cell Lung Cancer
- 作者: Kolegova E.1, Kakurina G.1, Kondakova I.1, Dobrodeev A.1, Kostromitskii D.2, Zhuikova L.1
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隶属关系:
- Tomsk National Research Medical Center, Russian Academy of Science
- Tomsk Regional Oncology Center
- 期: 卷 167, 编号 3 (2019)
- 页面: 393-395
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241737
- DOI: https://doi.org/10.1007/s10517-019-04534-9
- ID: 241737
如何引用文章
详细
We studied the expression of mRNA and the level of CAP1 (adenylate cyclase-associated protein 1) and cofilin proteins in the tissues of patients with non-small cell lung cancer. The expression of mRNA and the level of CAP1 in tumor tissue increased during growth of the primary tumor and its metastasis. It was shown that with the growth of the primary tumor, the content of cofilin in the tumor tissue decreases against the background of increased expression of its mRNA; in regional metastasis, the content of cofilin and expression of the corresponding mRNA increased. It was found that increased content of the studied proteins in the tumor tissue increased the risk of metastasis.
作者简介
E. Kolegova
Tomsk National Research Medical Center, Russian Academy of Science
编辑信件的主要联系方式.
Email: elenakolegova@oncology.tomsk.ru
俄罗斯联邦, Tomsk
G. Kakurina
Tomsk National Research Medical Center, Russian Academy of Science
Email: elenakolegova@oncology.tomsk.ru
俄罗斯联邦, Tomsk
I. Kondakova
Tomsk National Research Medical Center, Russian Academy of Science
Email: elenakolegova@oncology.tomsk.ru
俄罗斯联邦, Tomsk
A. Dobrodeev
Tomsk National Research Medical Center, Russian Academy of Science
Email: elenakolegova@oncology.tomsk.ru
俄罗斯联邦, Tomsk
D. Kostromitskii
Tomsk Regional Oncology Center
Email: elenakolegova@oncology.tomsk.ru
俄罗斯联邦, Tomsk
L. Zhuikova
Tomsk National Research Medical Center, Russian Academy of Science
Email: elenakolegova@oncology.tomsk.ru
俄罗斯联邦, Tomsk