Association between Disturbances in Polyunsaturated Fatty Acid Metabolism and Development of Oxidative Stress during Experimental Diabetes Mellitus
- Авторлар: Mikaelyan N.1, Dvornikov A.1, Mikaelyan A.1, Smirnova N.1
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Мекемелер:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 167, № 3 (2019)
- Беттер: 343-346
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241689
- DOI: https://doi.org/10.1007/s10517-019-04523-y
- ID: 241689
Дәйексөз келтіру
Аннотация
We studied the effect of streptozotocin-induced diabetes mellitus on the level of glycemia and some other indices of lipid metabolism, including fatty acid metabolism and LPO intensity, during the development of diabetes mellitus in rats. Even at the early terms of diabetes development, hypertriglyceridemia and hypercholesterolemia were accompanied by changes in the blood content of fatty acid (at the expense of ω3 and ω6 fatty acids) that persisted throughout the observation period. Intensification of LPO against the background of suppressed activity of antioxidant enzymes and reduced level of ω3 fatty acids attested to the development of oxidative stress. These data attest to antioxidant property of ω3 fatty acids, which is seen from positive correlations between these fatty acids and activity of antioxidant enzymes.
Авторлар туралы
N. Mikaelyan
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: ninmik@yandex.ru
Ресей, Moscow
A. Dvornikov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ninmik@yandex.ru
Ресей, Moscow
A. Mikaelyan
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ninmik@yandex.ru
Ресей, Moscow
N. Smirnova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ninmik@yandex.ru
Ресей, Moscow