Association between Disturbances in Polyunsaturated Fatty Acid Metabolism and Development of Oxidative Stress during Experimental Diabetes Mellitus
- Authors: Mikaelyan N.P.1, Dvornikov A.S.1, Mikaelyan A.A.1, Smirnova N.V.1
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Affiliations:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 167, No 3 (2019)
- Pages: 343-346
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241689
- DOI: https://doi.org/10.1007/s10517-019-04523-y
- ID: 241689
Cite item
Abstract
We studied the effect of streptozotocin-induced diabetes mellitus on the level of glycemia and some other indices of lipid metabolism, including fatty acid metabolism and LPO intensity, during the development of diabetes mellitus in rats. Even at the early terms of diabetes development, hypertriglyceridemia and hypercholesterolemia were accompanied by changes in the blood content of fatty acid (at the expense of ω3 and ω6 fatty acids) that persisted throughout the observation period. Intensification of LPO against the background of suppressed activity of antioxidant enzymes and reduced level of ω3 fatty acids attested to the development of oxidative stress. These data attest to antioxidant property of ω3 fatty acids, which is seen from positive correlations between these fatty acids and activity of antioxidant enzymes.
About the authors
N. P. Mikaelyan
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: ninmik@yandex.ru
Russian Federation, Moscow
A. S. Dvornikov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ninmik@yandex.ru
Russian Federation, Moscow
A. A. Mikaelyan
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ninmik@yandex.ru
Russian Federation, Moscow
N. V. Smirnova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ninmik@yandex.ru
Russian Federation, Moscow