Effect of Endogenous Neuropeptide Cycloprolylglycine on GABAA Receptors in Cerebellar Purkinje Cells
- Авторлар: Sharonova I.1, Bukanova Y.1, Gudasheva T.2, Skrebitsky V.1
-
Мекемелер:
- Research Center of Neurology
- V. V. Zakusov Research Institute of Pharmacology
- Шығарылым: Том 167, № 1 (2019)
- Беттер: 39-42
- Бөлім: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241426
- DOI: https://doi.org/10.1007/s10517-019-04455-7
- ID: 241426
Дәйексөз келтіру
Аннотация
Voltage clamp and concentration-jump methods were employed to examine the effects of endogenous neuropeptide cycloprolylglycine on GABA-activated ionic currents in isolated cerebellar Purkinje cells. In the concentration range of 0.1-10.0 μM, short-term (600 msec) external application of cycloprolylglycine against the background of GABA-evoked current produced no effect on its amplitude. In contrast, application of 1 μM cycloprolylglycine increased current up to 177±15% control level. The development of potentiating effect and return to the control level of ionic current were slow, which was indicative of possible implication of second messenger systems in these processes. Functional augmentation of GABAA receptors under the action of cycloprolylglycine can underlie the established neuroprotective and anxiolytic effects of this endogenous dipeptide.
Авторлар туралы
I. Sharonova
Research Center of Neurology
Хат алмасуға жауапты Автор.
Email: sharonova.irina@gmail.com
Ресей, Moscow
Yu. Bukanova
Research Center of Neurology
Email: sharonova.irina@gmail.com
Ресей, Moscow
T. Gudasheva
V. V. Zakusov Research Institute of Pharmacology
Email: sharonova.irina@gmail.com
Ресей, Moscow
V. Skrebitsky
Research Center of Neurology
Email: sharonova.irina@gmail.com
Ресей, Moscow