Effect of Endogenous Neuropeptide Cycloprolylglycine on GABAA Receptors in Cerebellar Purkinje Cells
- Авторы: Sharonova I.1, Bukanova Y.1, Gudasheva T.2, Skrebitsky V.1
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Учреждения:
- Research Center of Neurology
- V. V. Zakusov Research Institute of Pharmacology
- Выпуск: Том 167, № 1 (2019)
- Страницы: 39-42
- Раздел: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241426
- DOI: https://doi.org/10.1007/s10517-019-04455-7
- ID: 241426
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Аннотация
Voltage clamp and concentration-jump methods were employed to examine the effects of endogenous neuropeptide cycloprolylglycine on GABA-activated ionic currents in isolated cerebellar Purkinje cells. In the concentration range of 0.1-10.0 μM, short-term (600 msec) external application of cycloprolylglycine against the background of GABA-evoked current produced no effect on its amplitude. In contrast, application of 1 μM cycloprolylglycine increased current up to 177±15% control level. The development of potentiating effect and return to the control level of ionic current were slow, which was indicative of possible implication of second messenger systems in these processes. Functional augmentation of GABAA receptors under the action of cycloprolylglycine can underlie the established neuroprotective and anxiolytic effects of this endogenous dipeptide.
Об авторах
I. Sharonova
Research Center of Neurology
Автор, ответственный за переписку.
Email: sharonova.irina@gmail.com
Россия, Moscow
Yu. Bukanova
Research Center of Neurology
Email: sharonova.irina@gmail.com
Россия, Moscow
T. Gudasheva
V. V. Zakusov Research Institute of Pharmacology
Email: sharonova.irina@gmail.com
Россия, Moscow
V. Skrebitsky
Research Center of Neurology
Email: sharonova.irina@gmail.com
Россия, Moscow
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