Мақаланы E-mail арқылы жіберу The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart
- Авторлар: Lasukova T.1,2, Zykova M.3, Belousov M.3, Gorbunov A.2, Logvinova L.3, Dygai A.4
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Мекемелер:
- Tomsk State Pedagogical University
- Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of the Russian Federation
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Шығарылым: Том 166, № 5 (2019)
- Беттер: 598-601
- Бөлім: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241219
- DOI: https://doi.org/10.1007/s10517-019-04399-y
- ID: 241219
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.
Авторлар туралы
T. Lasukova
Tomsk State Pedagogical University; Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: tlasukova@mail.ru
Ресей, Tomsk; Tomsk
M. Zykova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: tlasukova@mail.ru
Ресей, Tomsk
M. Belousov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: tlasukova@mail.ru
Ресей, Tomsk
A. Gorbunov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: tlasukova@mail.ru
Ресей, Tomsk
L. Logvinova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: tlasukova@mail.ru
Ресей, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: tlasukova@mail.ru
Ресей, Tomsk
