Enviar artigo por via de e-mail The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart
- Autores: Lasukova T.V.1,2, Zykova M.V.3, Belousov M.V.3, Gorbunov A.S.2, Logvinova L.A.3, Dygai A.M.4
-
Afiliações:
- Tomsk State Pedagogical University
- Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of the Russian Federation
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Edição: Volume 166, Nº 5 (2019)
- Páginas: 598-601
- Seção: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241219
- DOI: https://doi.org/10.1007/s10517-019-04399-y
- ID: 241219
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.
Sobre autores
T. Lasukova
Tomsk State Pedagogical University; Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Autor responsável pela correspondência
Email: tlasukova@mail.ru
Rússia, Tomsk; Tomsk
M. Zykova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: tlasukova@mail.ru
Rússia, Tomsk
M. Belousov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: tlasukova@mail.ru
Rússia, Tomsk
A. Gorbunov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: tlasukova@mail.ru
Rússia, Tomsk
L. Logvinova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: tlasukova@mail.ru
Rússia, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: tlasukova@mail.ru
Rússia, Tomsk
Arquivos suplementares
