Email this article The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart
- Authors: Lasukova T.V.1,2, Zykova M.V.3, Belousov M.V.3, Gorbunov A.S.2, Logvinova L.A.3, Dygai A.M.4
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Affiliations:
- Tomsk State Pedagogical University
- Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of the Russian Federation
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Issue: Vol 166, No 5 (2019)
- Pages: 598-601
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241219
- DOI: https://doi.org/10.1007/s10517-019-04399-y
- ID: 241219
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Abstract
The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.
About the authors
T. V. Lasukova
Tomsk State Pedagogical University; Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Author for correspondence.
Email: tlasukova@mail.ru
Russian Federation, Tomsk; Tomsk
M. V. Zykova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: tlasukova@mail.ru
Russian Federation, Tomsk
M. V. Belousov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: tlasukova@mail.ru
Russian Federation, Tomsk
A. S. Gorbunov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: tlasukova@mail.ru
Russian Federation, Tomsk
L. A. Logvinova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: tlasukova@mail.ru
Russian Federation, Tomsk
A. M. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: tlasukova@mail.ru
Russian Federation, Tomsk
