Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia
- Авторлар: Dzhalilova D.1, Diatroptov M.1, Tsvetkov I.1, Makarova O.1, Kuznetsov S.2
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Мекемелер:
- Research Institute of Human Morphology
- I. M. Sechenov First Moscow State Medical University
- Шығарылым: Том 165, № 6 (2018)
- Беттер: 781-785
- Бөлім: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/240748
- DOI: https://doi.org/10.1007/s10517-018-4264-x
- ID: 240748
Дәйексөз келтіру
Аннотация
We studied the expression of Hif-1α, Nf-κb, and Vegf genes in the liver and serum levels of HIF-1α, erythropoietin, VEGF, TGF-β, 8-isoprostane, and corticosterone in Wistar rats with different resistance to hypoxia in 5 and 90 min after acute exposure to hypobaric hypoxia. In 5 min after hypoxic exposure, Hif-1α expression in the liver and serum levels of erythropoietin, VEGF, and TGF-β in high-resistant rats were higher than in low-resistant animals. In highresistant rats, the increment in expression of Nf-κb gene responsible for the control over the inflammatory processes was more pronounced than in low-resistant animals. In 90 min after hypoxic exposure, the serum levels of HIF-1α, erythropoietin, VEGF, and TGF-β returned to normal in high-resistant rats, while in low-resistant animals, an increase in 8-isoprostane and TGF-β concentrations was observed. The rats with different resistance to hypoxia were characterized by different changes in biomolecular parameters determining predilection to inflammatory diseases.
Авторлар туралы
D. Dzhalilova
Research Institute of Human Morphology
Хат алмасуға жауапты Автор.
Email: juliajal93@mail.ru
Ресей, Moscow
M. Diatroptov
Research Institute of Human Morphology
Email: juliajal93@mail.ru
Ресей, Moscow
I. Tsvetkov
Research Institute of Human Morphology
Email: juliajal93@mail.ru
Ресей, Moscow
O. Makarova
Research Institute of Human Morphology
Email: juliajal93@mail.ru
Ресей, Moscow
S. Kuznetsov
I. M. Sechenov First Moscow State Medical University
Email: juliajal93@mail.ru
Ресей, Moscow