Мақаланы E-mail арқылы жіберу Effect of Lithium Preparations on Cerebral Electrophysiological Activity in Rats
- Авторлар: Konenkov V.1, Rachkovskaya L.1, Letyagin A.1, Suslov N.2, Shurlygina A.1, Robinson M.1, Korolev M.1, Kotlyarova A.1, Popova T.1, Rachkovskii E.1, Povet’eva T.2, Shilova N.2, Nesterova Y.2, Afanas’eva O.2, Kul’pin P.2
-
Мекемелер:
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Шығарылым: Том 165, № 4 (2018)
- Беттер: 470-473
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240426
- DOI: https://doi.org/10.1007/s10517-018-4196-5
- ID: 240426
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
The study examined the effects of a novel neurotropic medication based on a lithium complex composed of lithium citrate, polymethylsiloxane, and aluminum oxide on electrophysiological parameters of the rat brain. In contrast to lithium carbonate (the reference drug), the novel preparation resulted in a wave-like dynamics of electrical activity in the visual cortex. Rhythmic photic stimulation of the rats treated with lithium carbonate resulted in appearance of the signs attesting to up-regulation of excitability of cerebral cortex in all examined ranges. In contrast, the complex lithium preparation diminished the delta power spectrum, which was the only affected frequency band. It is hypothesized that the complex lithium medication induces milder activation of the cerebral cortex in comparison with lithium carbonate. The novel medication composed of lithium citrate, aluminum oxide, and polymethylsiloxane, is characterized by greater efficacy and safety than the preparation based on inorganic lithium salt (lithium carbonate).
Авторлар туралы
V. Konenkov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Novosibirsk
L. Rachkovskaya
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Novosibirsk
A. Letyagin
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Novosibirsk
N. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Tomsk
A. Shurlygina
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: anna_v_s@mail.ru
Ресей, Novosibirsk
M. Robinson
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Novosibirsk
M. Korolev
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Novosibirsk
A. Kotlyarova
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Novosibirsk
T. Popova
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Novosibirsk
E. Rachkovskii
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Novosibirsk
T. Povet’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Tomsk
N. Shilova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Tomsk
Yu. Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Tomsk
O. Afanas’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Tomsk
P. Kul’pin
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Ресей, Tomsk
